2/21/2023 0 Comments Pathological lymph nodeThis retrospective study according to the Declaration of Helsinki was performed at the Department of Head and Neck Surgery in our institution, and approved by our institutional review board (receipt number 2019–1-427). Therefore, we aimed to investigate whether LNR and LODDS in patients with MiSGC were significantly correlated with survival outcomes. Although the pathological predictors for MiSGC of the head and neck were indicated in a recent review article, other predictors must be determined as this is a rare malignancy. Mucoepidermoid carcinoma (MEC) and adenoid cystic carcinoma are histologically reported two most common classifications, and the definitive treatment for MiSGC is surgery with or without postoperative radiation. Minor salivary gland carcinoma (MiSGC) is a rare neoplasma in head and neck, accounting for 0.16 to 0.4% of new cases per 100, 000 population. For the absence of positive lymph nodes described, LNR or LODDS represent the same value = 0 or avoids singularities, respectively. Both lymph node ratio (LNR) and log odds of positive lymph nodes (LODDS) as pathological continuous variables, which were regulated by nodal staging, surgery, and sampling, were applied regardless of various types for neck dissection. Representative continuous variables of lymph nodes was the number of positive lymph nodes after neck dissection surgery. Lymph node on pathological examination is investigated as useful predictors of survival results in several types of cancer. ConclusionĪ higher lymph node ratio of minor salivary gland carcinoma is a predictor of shorter survival results. Lymph node ratio ≥ 0.05 was associated with shorter disease-specific (hazard ratio = 7.90, 95% confidence interval = 1.54–57.1), disease-free (hazard ratio = 4.15, 95% confidence interval = 1.48–11.2) and overall (hazard ratio = 4.84, 95% confidence interval = 1.05–24.8) survival in the multivariate analysis. Both lymph node ratio and log odds of positive lymph nodes were significantly related with survival outcomes by the univariate analysis. Lymph node ratio = 0.05 as well as log odds of positive lymph nodes = − 2.73 predicted the carcinoma-specific death. Log-rank test and Cox’s proportional hazards model were used for uni−/multi-variate survival analyses adjusting for pathological stage, respectively. Receiver operating curve analysis was used for the cut-off values of the carcinoma-specific death. The pathological continuous variables were evaluated by the number of positive lymph nodes, lymph node ratio, and log odds of positive lymph nodes. Methodsįorty-four cases with minor salivary gland carcinoma who underwent both primary resection and neck dissection were retrospectively enrolled. We investigate whether pathological continuous variables of lymph nodes were related with survival results of carcinomas of minor salivary gland carcinoma in head and neck.
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